Guide is the first NPC that you encounter, and spawns right away with a new world. He provides tips that are mainly for new players to learn the basics of the game. The Guide also provides information on what you can craft out of any item, just by showing it to him. Unlike other NPCs, he does not need a house, but will move into the first one built, which will often be yours. You may want to build two houses, first one for the guide, second one for yourself. If killed, the guide won't respawn until you make a house for him to inhabit.
The Guide can die. He will respawn in either your house or another vacant house that is correctly built for an NPC. After the Guide has said everything he will repeat them again. As most players know that he will take the first available home, many find him annoying, though no longer pointless as he now tells you crafting recipes.
"Greetings, <player name>. Is there something I can help you with?"
"I am here to give you advice on what to do next. It is recommended that you talk with me anytime you get stuck."
"They say there is a person who will tell you how to survive in this land... oh wait. That's me."
During the Night
"You should stay indoors at night. It is very dangerous to be wandering around in the dark."
"You can tell a Blood Moon is out when the sky turns red. There is something about it that causes monsters to swarm."
"Hey, buddy, do you know where any deathweed is? Oh, no reason; just wondering, is all."
"If you were to look up, you'd see that the moon is red right now."
"You can use your pickaxe to dig through dirt, and your axe to chop down trees. Just place your cursor over the tile and click!"
"If you want to survive, you will need to create weapons and shelter. Start by chopping down trees and gathering wood."
"Press ESC to access your crafting menu. When you have enough wood, create a workbench. This will allow you to create more complicated things, as long as you are standing close to it."
"You can build a shelter by placing wood or other blocks in the world. Don't forget to create and place walls."
"Once you have a wooden sword, you might try to gather some gel from the slimes. Combine wood and gel to make a torch!"
"To interact with backgrounds and placed objects, use a hammer!"
"You should do some mining to find metal ore. You can craft very useful things with it."
After some mining
"Now that you have some ore, you will need to turn it into a bar in order to make items with it. This requires a furnace!"
"You can create a furnace out of torches, wood, and stone. Make sure you are standing near a work bench."
"You will need an anvil to make most things out of metal bars."
" Anvils can be crafted out of iron, or purchased from a merchant."
"Underground are crystal hearts that can be used to increase your max life. You will need a hammer to obtain them."
"If you gather 10 fallen stars, they can be combined to create an item that will increase your magic capacity."
"Stars fall all over the world at night. They can be used for all sorts of useful things. If you see one, be sure to grab it because they disappear after sunrise."
Tipps regarding NPCs
Note: Tipps targeting a specific NPC will only show up if the respective NPC isn't present
"There are many different ways you can attract people to move in to our town. They will of course need a home to live in."
"In order for a room to be considered a home, it needs to have a door, chair, table, and a light source. Make sure the house has walls as well."
"Two people will not live in the same home. Also, if their home is destroyed, they will look for a new place to live."
"You can use the housing interface to assign and view housing. Open you inventory and click the house icon."
"If you want a merchant to move in, you will need to gather plenty of money. 50 silver coins should do the trick!"
"For a nurse to move in, you might want to increase your maximum life."
"If you had a gun, I bet an arms dealer might show up to sell you some ammo!"
"Hang on to any bombs you might find. A demolitionist may want to have a look at them."
"You should prove yourself by defeating a strong monster. That will get the attention of a dryad."
Once you defeated Skeletron:
"Make sure to explore the dungeon thoroughly. There may be prisoners held deep within."
"Perhaps the old man by the dungeon would like to join us now that his curse has been lifted."
After first Goblin event:
"Are goblins really so different from us that we couldn't live together peacefully?"
Tipps regarding Bosses
"You can make a grappling hook from a hook and 3 chains. Skeletons found deep underground usually carry hooks, and chains can be made from iron bars."
"If you see a pot, be sure to smash it open. They contain all sorts of useful supplies."
"There is treasure hidden all over the world. Some amazing things can be found deep underground!"
"Smashing a shadow orb will sometimes cause a meteor to fall out of the sky. Shadow orbs can usually be found in the chasms around corrupt areas."
"You should focus on gathering more heart crystals to increase your maximum life."
Tipps for first boss fight
When you have Iron or lower equipment
"Your current equipment simply won't do. You need to make better armor."
When you have silver or better equipment and didn't battled the Eye of Cthulhu yet.
"I think you are ready for your first major battle. Gather some lenses from the eyeballs at night and take them to a demon altar."
When Eye of Cthulhu was already battled
"You will want to increase your life before facing your next challenge. Fifteen hearts should be enough."
"The ebonstone in the corruption can be purified using some powder from a dryad, or it can be destroyed with explosives."
"Your next step should be to explore the corrupt chasms. Find and destroy any shadow orb you find."
Tipps for late Pre-Hardmode
"There is a old dungeon not far from here. Now would be a good time to go check it out."
"You should make an attempt to max out your available life. Try to gather twenty hearts."
"There are many treasures to be discovered in the jungle, if you are willing to dig deep enough."
"The underworld is made of a material called hellstone. It's perfect for making weapons and armor."
"When you are ready to challenge the keeper of the underworld, you will have to make a living sacrifice. Everything you need for it can be found in the underworld."
"Make sure to smash any demon altar you can find. Something good is bound to happen if you do!"
"Souls can sometimes be gathered from fallen creatures in places of extreme light or dark."
"I heard there was a powerful wizard who lives somewhere in these parts. Make sure to keep an eye out for him the next time you go underground."
Note: Upon adding a new name, make sure you add it in alphabetical (ABC) order.
Sometimes the Guide will say "Hang on to any bombs you might find. A Demolitionist may want to to take a look at them" when the Demolitionist is already present.
Sometimes the guide will automatically craft an item using your items when asking for a recipe.
Update Info Edit
Guide now tells you what you can craft from any material (when that item states it is a Material)
Can now be killed by monsters
Lowered defense from 199 to 15