We all have our special weapons, the ones we used a lot and that served us well through many days of battle in Terraria. You tend to grow an affinity for them after awhile, and learn how to use them. They become part of you - for example, no Terrarian in their right mind would draw me without an Emerald Staff. What are yours?
I'd have to say mine are the Blue Moon, Night's Edge and Emerald Staff. I've used those three into Hardmode, and they have all served me very well. I have a special fondness for the Emerald Staff, just because of how it saved my bacon so many times. The Night's Edge has been upgraded to the True Night's Edge and continues to serve me well.