Take into account that I am pretty new to the game:
1. Defeat the Brain of Cthulu. I have tried before but did horrible, but my new upgrades should do well.
2. Find a sky island.I already made a sky bridge and I have a few gravitational potions savedup, so I should find one soon.
3. Get to the underworld. I don't know if I'm ready with my meteor armor, but I have some shadow keys saved up.
4. Get to the 50th Angler quest.
Achieved goals: Found an underground jungle, got the Umbrella, killed Skeletron, and built a nice sky bridge.